CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons.

Wang, X.Q., Deriy, L.V., Foss, S., Huang, P., Lamb, F.S., Kaetzel, M.A., Bindokas, V., Marks, J.D., Nelson, D.J. (2006) Neuron  52, 321-333 [Abstract]

Functional interaction of CLC-3, CaMKII, and annexin IV in a colonic cell line HT29.

Robinson, N.C., Di, A., Huang, P., Liu, J., Kaetzel, M.A., Wang, J.Y., and Nelson, D.J.    In revision J. Physiol. 

5-amino-imidazole carboxamide riboside (AICAR) promotes glucose-induced insulin secretion from mouse pancreatic islets.

Wang, C-Z., Wang, Y., Di, A., Magnuson, M.A., Duan, Y-L., Ye, H., Roe, M.W., Nelson, D.J., Philipson, L., and Bell, G.I. Submitted.

CFTR controls elimination of phagocytosed bacteria in macrophages. 

Di, A., Huang, P., Libunao, F., Bindokas, V., Palfrey, H.C., Roy, K. Naren, A.P., and Nelson, D.J.  In revision  Nature Medicine.

 Disruption of GIRK channel function and termini association upon mutation of a critical Girk1 C-terminal residue. 

Sarac, R., Hou, P., Hurley, K.M., Hriciste, D., and Nelson., D.J.  In Revision J. Neuroscience

A process for controlling intracellular bacterial infections induced by membrane injury.

Roy, D., Liston, D.R., Idone. V., Di, A., Nelson, D.J., Pujol, C., Bliska, J.B., Chakrabarti, S., Andrews, N.W. 2004    Science 304:1515-1518 [Abstract]  [PDF]

Identification of an N-Terminal Amino Acid of CLC-3 Critical in Phosphorylation-Dependent Activation of I_Cl,CaMKII..

Robinson, N. C., Huang, P., Kaetzel, M.A., Lamb, F. S., and Nelson,  D.J. 2004  J. Physiol. 556.2:353-368.[Abstract]  [PDF]

Expression of an autonomous Ca²⁺-calmodulin dependent kinase II in the intestinal epithelium improves survival of the CFTR^MIUNC mouse.

Kaetzel, M.A., Gunteski-Hamblin, A.-M., Nelson, D.J., Ecay, T. and Dedman, J.R.     Submitted.

Dynamin regulates focal exocytosis in phagocytosing macrophages. 

Di, A., Nelson, D.J., Bindokas, V., Brown, M.E., Libunao, L.F., and Palfrey, H.C. 2003   Molecular Biology of the Cell  14:2016-2028.[Abstract]  [PDF]

 The interaction between syntaxin 1A and CFTR Cl^- channels is mechanistically distinct from syntaxin 1A-SNARE interactions. 

Ganeshan, R., Di, A., Nelson, D.J., Quick, M.W., and Kirk, K.L. 2003   J. Biol. Chem. 278: 2876-2885.[Abstract]  [PDF]

CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex.

Cormet-Boyaka, E., Di, A., Chang, S.Y., Naren, A.P., Tousson, A., Nelson, D.J., and Kirk, K.L. 2002   Proc. Nat. Acad. Sci. 99:12477-12482. [Abstract]  [PDF]

Mechanisms of CFTR regulation by Syntaxin 1A and PKA.

Chang, S.Y., Di, A., Naren, A.P., Palfrey, H.C., Kirk, K.L., and Nelson D.J. 2002  J. Cell Science 115:783-791.[Abstract]  [PDF]

Quantal release of free radicals during exocytosis of phagosomes. 

Di, A., Krupa, B., Bindokas, V.P., Chen, Y., Brown, M.E, Palfrey, H.C., Naren, A.P., Kirk, K.L. and  Nelson, D.J.  2002.   Nature Cell Biology 4:279-285 . [Abstract]  [PDF]

 Calcium-G protein interactions in the regulation of macrophage secretion.

Di, A., Krupa, B., and Nelson, D.J.  2001    J. Biol. Chem. 276: 37124-37132. [Abstract]  [PDF]

Priming of insulin granules for exocytosis by granular chloride uptake and acidification. 

Barg, S. Eliasson, L., Huang, P., Nelson, D.J., Thevenod, F., and Renstrom, E. 2001.   J. Cell Science  114:2145-2154. [Abstract]  [PDF]

Oxidants potentiate Ca⁺⁺ and c-AMP stimulated Cl^- secretion in intestinal epithelial T84 cells. 

Sugi, K, Musch, M.W., Nelson, D.J., and Chang, E.B.  2001   Gastroenterology. 120:89-98. [Abstract]

Regulation of human ClC-3 channels by multifunctional Ca²⁺/calmodulin dependent  protein kinase. 

Huang, P., Liu, J., Di, A., Robinson, N.C., Musch, M.W., Kaetzel, M.A. and Nelson, D.J.  2001. J. Biol. Chem. 276:20093-20100.[Abstract]  [PDF]

 Syntaxin 1A is expressed in airway epithelial cells where it modulates CFTR Cl^- currents.

Naren, A.P., Di, A., Cormet-Boyaka, E., Boyaka, P.N., McGhee, J. R., Zhou, W., Akagawa, K., Fujiwara, T., Thome, U., Engelhardt, J.F., Nelson, D.J., and  Kirk, K.L.  2000  J. Clinical Investigation.  105:377-386.[Abstract]  [PDF]

 Impermeability of the GIRK2 weaver channel to divalent cations.

Hou, Ping, Di, Anke, Huang, Ping, Hansen, C.B, and Nelson, D.J.  2000  Am. J. Physiology (Cell) 278:C1038-C1046.[Abstract]  [PDF]

 Inwardly rectifying K⁺ channel subunit GIRK1 rescues the GIRK2 weaver phenotype.

51.Hou, P., Yan, S., Tang, W., and Nelson, D.J.  1999      J. Neuroscience 19: 8327-8336.[Abstract]  [PDF]

Alternative splicing of SUR2 exon 17 regulates nucleotide sensitivity of the ATP-sensitive K channel.

Chutkow, W.A., Makielski, J.C., Nelson, D.J., Burant, C.F., and Fan, Z. 1999   J. Biol. Chem. 274:13656-13665. [Abstract]  [PDF]

Membrane capacitance changes with particle uptake during phagocytosis in macrophages. 

Holevinsky, K.O., and Nelson, D.J.  1998.  1998.   Biophys. J.  75: 2577-2586. [Abstract]

 Altered responses to potassium in cerebellar neurons from Weaver heterozygote mice.

Fox, A.P., Dlouhy, S.,  Ghetti, B., Hurley, J.H., Nucifora, P.G.P., Nelson, D. J., Won, L., and Heller, A.  1998.    Exp. Br. Res.  123: 298-306.[Abstract]  [PDF]

Synthesis of D-1,2-dideoxy-1,2-difluoro-myo-inositol 3,4,5,6-tetrakisphosphate and its enantiomer as analogues of myo-inositol 3,4,5,6-tetrakisphosphate.

Solomons, K.R.H., Freeman, S., Schwalbe, C.H., Shears, S.B., Nelson, D.J., Xie, W., Bruzik, K.S. and Kaetzel, M.A.  1998.    Carb. Res. .  309: 337-343.

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.

Naren, P.P., Quick, M.W., Collawn, J.F., Nelson, D.J., and Kirk, K.L.    1998.  Proc. Nat. Acad. Sci.  95: 10972-10977.[Abstract]  [PDF]

 Regulation of Ca2⁺-dependent Cl^- conductance in a human colonic epithelial cell line (T₈₄): cross-talk between Ins   (3,4,5,6)P₄ and protein phosphatases.

Xie, W., Solomons, K.R.H., Freeman, S., Kaetzel, M.A., Bruzik, K.S., Nelson, D.J., and Shears, S.B.  1998.    J. Physiol.  510: 661-673. [Abstract]  

Cytoskeletal actin gates a Cl^- channel in neocortical astrocytes. 

Lascola, C.D., Nelson, D.J., Kraig, R.P.  1998.   J. Neurosci.  18: 1679-1692.[Abstract]  [PDF]

Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms. 

Naren, A.P., Nelson, D.J., Xie, W., Jovov, B.A., Pevsner, J., Bennett, M.K., Benos, D.J., Quick, M.W., and Kirk, K. L.  1997.   Nature.  390: 302-305.[Abstract]  [PDF]

N-type inactivation in the mammalian Shaker K⁺ channel Kv1.4. 

Lee, T.E., Philipson, L. H., and Nelson, D.J.  1996. J. Memb. Biol.  151: 225-235. [Abstract]  [PDF]

Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloried conductance in T84 colonic epithelial cells. 

Xie, W., Kaetzel, M.A., Bruzik, K.S., Dedman, J.R., Shears, S.B., and Nelson, D.J.  1996.   J. Biol. Chem.  271: 14092-14098.[Abstract]  [PDF]

Shrinkage activates a non-selective conductance:  Involvement of a Walker-Motif protein and protein kinase

Nelson, D.J., Tien, X-Y., Xie, W., Brasitus, T.A., Kaetzel, M.A., and Dedman, J.R.  1996. C.  Am. J. Physiol.  270: C179-C191.[Abstract]

Calcium signaling in cultured rat oligodendrocytes.

Takeda, M., Nelson, D.J., and Soliven, B.  1995.    Glia  14: 225-236. [Abstract]

 Extracellular pH modulates the Ca²⁺ current activated by depletion of intracellular Ca²⁺ stores in human macrophages. 

Malayev, A., and Nelson, D.J.  1995.  J. Memb. Biol.  146:  101-111.[Abstract]

Simultaneous detection of free radical release and membrane current in macrophages during phagocytosis. 

Holevinsky, K.O. and Nelson, D.J.  1995.    J. Biol. Chem. 270: 8328-8336.[Abstract]  [PDF]

Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel. 

Malayev, A.A., Nelson, D.J., and Philipson, L.H.  1995. J. Molec. Pharm.  47:  198-205.[Abstract]

Annexin IV inhibits calmodulin-dependent protein kinase II activated chloride conductance:  A novel mechanism for ion channel regulation.  

Chan, H.C., Kaetzel, M.A., Gotter, A.L., Dedman, J. R., and Nelson,  D.J.  1994.   J. Biol. Chem.  269:  32464-32468.[Abstract]  [PDF]

Alternative splicing of human inwardly rectifying K⁺ channel ROMK1 mRNA. 

Yano, H., Philipson, L.H., Kugler, J., Tokuyama, Y., Davis, E.M., Le Beau, M.M., Nelson, D.J., Bell, G.I., and Takeda, J.  1994.   J. Molec. Pharm.  45:  854-860.[Abstract]

Elevation in intracellular calcium activates both chloride and proton currents in human macropohages.  

Holevinsky, K., Jow, F., and Nelson, D.J.  1994.   J. Memb. Biol.  140:  13-30.[Abstract]

Structural determinant for the assembly of mammalian K⁺ channels. 

Lee, T.E., Philipson, L.H., Kusnetsov, A., and Nelson, D.J.  1994.  Biophys. J.  66: 667-673.[Abstract]

A role for annexin IV in epithelial cell function:  Inhibition of calcium-activated chloride conductance. 

Kaetzel, M.A., Chan, H.-C., Dubinsky, W.P., Dedman, J.R., and Nelson, D.J. 1994.  J. Biol. Chem.  269: 5297-5302.[Abstract]  [PDF]

ATP-sensitive K⁺ channel opener acts as a potent Cl^- channel inhibitor in vascular smooth muscle cells. 

Holevinsky, K., Fan, Z., Frame, M., Makielski, J., Groppi, V., and Nelson, D.J.  1994.  J. Memb. Biol. 137: 59-70.[Abstract]

Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2. 

Tien, X-Y, Brasitus, T.A., Kaetzel, M.A., Dedman, J.R., and Nelson, D.J.  1994. J. Biol. Chem.  269: 51-54.[Abstract]

Functional and biochemical characterization of the human potassium channel Kv1.5 with a transplanted carboxyl-terminal epitope in stable mammalian cell lines. 

Philipson, L.H., Malayev, A., Kuznetsov, A., Chang, C., and Nelson, D.J. 1993. Biochem. Biophys. Acta (Biomembranes) 1153: 111-121.[Abstract]

Characterization of the 1,25-dihydroxycholecalciferol-stimulated calcium influx pathway in CaCo-2 cells. 

Tien, X-Y., Katnik, C., Qasawa, B.M., Sitrin, M., Nelson, D.J., and Brasitus, T.A.  1993.  J. Memb. Biol. 136: 159-168.[Abstract]

Selection of targeted biological modifiers from a bacteriophage library of random peptides:  The identification of novel calmodulin regulatory peptides. 

Dedman, J.R., Kaetzel, M.A., Chan, H.C., Nelson, D.J. and Jamieson, Jr., G.A.  1993.  J. Biol. Chem. 268:  23025-23030.[Abstract]  [PDF]

 Platelet activating factor-induced increase in cytosolic calcium and transmembrane current in human macrophages. 

Katnik, C. and Nelson, D.J.  1993. J. Memb. Biol.  134:  213-224.[Abstract]

Arachidonic acid and its metabolites increase Ca_i in cultured rat oligodendrocytes. 

Soliven, B., Takeda, M., Shandy, T., and Nelson, D.J.  1993.  Am. J. Physiol. 264: C632-C640 [Abstract]

Chloride-dependent cation conductance activated during cellular shrinkage. 

Chan, H.-C., and Nelson, D.J.  1992.  Science 257: 669-671.[Abstract]

Alternate pathways for chloride conductance activation in normal and cystic fibrosis airway epithelial cells. 

Chan, H.-C., Goldstein, J. and Nelson, D.J.  1992.  Am. J. Physiol. 262: C1273-C1283.[Abstract]

Antibody against a cystic fibrosis transmembrane conductance regulator-derived synthetic peptide inhibits anion currents in human colonic cell line T84.

Chan, H.-C., Kaetzel, M.A., Nelson, D.J., Hazarika, P., and Dedman, J.R.  1992.    J. Biol. Chem. 267: 8411-8416.[Abstract]  [PDF]

 Lipopolysaccharide induction of outward potassium current expression in human monocyte-derived macrophages:  Lack of correlation with secretion. 

Nelson, D.J., Jow, B., and Jow F. 1992. J. Memb. Biol. 125: 207-218.[Abstract]

Tumor necrosis factor inhibits K⁺ current expression in cultured oligodendrocytes. 

Soliven, B., Szuchet, S., and Nelson, D.J. 1991.  J. Memb. Biol. 124: 127-137. [Abstract]

Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.   

Philipson, L.H., Hice, R.E., Schaefer, S.K., LaMendola, J., Bell, G.I., Nelson, D.J., and Steiner, D.F.  1991.  Proc. Nat. Acad. Sci. USA 88: 53-57. [Abstract]  

Channel-mediated and carrier-mediated uptake of K⁺ into cultured ovine oligodendrocytes. 

Hertz, L., Soliven, B., Hertz, E. and Szuchet, S. and Nelson, D.J. 1990.  Glia 3: 550-557. [Abstract]

Beta-adrenergic modulation of K⁺ current in human T lymphocytes. 

Soliven, B. and Nelson, D.J. 1990. J. Memb. Biol. 117: 263-274.[Abstract]

Whole-cell currents in macrophages II.  Alveolar macrophages. 

Nelson, D.J., Jow, B., and Popovitch, K.J. 1990.  J. Memb. Biol. 117: 45-55. [Abstract]

Whole-cell currents in macrophages I.  Human monocyte-derived macrophages. 

Nelson, D.J., Jow, B. and Jow, F. 1990.   J. Memb. Biol. 117: 29-44. [Abstract]

Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. 

Vartanian, T., Dawson, G., Soliven, B., Nelson, D.J. and Szuchet, S. 1989.   Glia 2: 370-379. [Abstract]

Voltage-gated chloride currents in cultured canine tracheal epithelial cells. 

Schoppa, N., Shorofsky, S.R., Jow, F. and Nelson, D.J. 1989.  J. Memb. Biol. 108: 73-90. [Abstract]

 Effects of a monoclonal anti-acetylcholine receptor antibody on the avian end-plate. 

Maselli, R.A., Nelson, D.J. and Richman, D.P. 1989. J. Physiol. 411: 271-283. [Abstract]

Expression and modulation of K⁺ currents in oligodendrocytes: possible role in myelinogenesis. 

Soliven, B., Szuchet, S., Arnason, B.G.W. and Nelson, D.J. 1989.   Developmental Neuroscience 11: 118-131. [Abstract]

Forskolin and phorbol esters modulate the same K⁺ conductance in cultured oligodendrocytes.

Soliven, B., Szuchet, S., Arnason, B.G.W. and Nelson, D.J. 1988.   J. Memb. Biol. 105: 177-186.[Abstract]

In-Vitro blockade of neuromuscular transmission by monoclonal anti-acetylcholine receptor antibodies. 

Maselli, R.A., Jow, F., Richman, D.P., and Nelson, D.J. 1988.   Annals of New York Acad. of Sci.  Advances in Neuroimmunology 540: 523-524. [Abstract]

Changes in respiratory burst activity during human monocyte differentiation in suspension culture. 

Zeller, J.M., Caliendo, J., Lint, T.F., and Nelson, D.J. 1988.   Inflammation 12: 585-595. [Abstract]

Voltage-gated potassium currents in cultured sheep oligodendrocytes. 

Soliven, B., Szuchet, S., Arnason, B.G.W. and Nelson, D.J. 1988.  J. Neuroscience 8: 2131-2141.[Abstract]  [PDF]

Effect of K⁺ channel blockers on lymphocyte activation is non-specific. 

Schell, S., Nelson, D.J., Fozzard, H.A. and Fitch, F.  1987. J. Immunol. 139: 3224-3230. [Abstract]

Immunoglobulin G-induced single ionic channels in human alveolar macrophage membranes. 

Nelson, D.J., Jacobs, E.R., Tang, J.M., Zeller, J.M., and Bone, R.C. 1985.   J. Clinical Investigation 76: 500-507. [Abstract]

Single channel recordings of apical membrane chloride conductance in A6 epithelial cells. 

Nelson, D.J., Tang, J.M. and Palmer, L.G. 1984. J. Memb. Biol. 80: 81-90. [Abstract]

Single channels observed in tissue cultured muscle. 

Nelson, D.J. and Sachs, F. 1979.  Nature 282: 861-863. [Abstract]

Volume changes and potential artifacts of epithelial cells of frog skin following impalement with microelectrodes filled with 3M KCl. 

Nelson, D.J., Ehrenfeld, J. and Lindemann, B. 1978. J. Memb. Biol.  Special Issue 40: 91-119. [Abstract]

The distribution, activity, and function of the cilia in the frog brain. 

Nelson, D.J. and Wright, E.M. 1974. J. Physiol. 243: 63-78. [Abstract]